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Nonteratogenic Effects. Reports of infants suffering from extended-time period barbiturate exposure in utero incorporated the acute withdrawal syndrome of seizures and hyperirritability from start to your delayed onset of up to 14 times (see DRUG ABUSE AND DEPENDENCE).Phenobarbital was introduced to marketplace in 1912 by the drug firm Bayer given

Following oral or parenteral administration, barbiturates readily cross the placental barrier and therefore are distributed all over fetal tissues with greatest concentrations found in the placenta, fetal liver and Mind. Fetal blood levels technique maternal blood levels next parenteral administration.Phenobarbital is usually contraindicated in pat